If the dome is built properly it will not interfere with the flow if you back the dome away from the edge closest to the intake valve and slowly raise the dome towards the CL of the piston. If you fill the CC area above the cylinder bore then you will interfere with the incoming air. Take the head off of your motor when you have it on the bench. Take a degree wheel, find TDC, then turn the crank in engine rotation and when you get towards the end of the exhaust stroke you will find that your intake valve is opening up, note the location of your piston, if the valve is opening and the air stream is wanting to flow, now imagine you have a tall dome on top of your piston. Where is the air going to go? If you plan on starting and stopping the air stream using only the remaining 3/4" of your intake stroke then you will not have good volumeteric efficiency. Note the crank degrees that your valve spends in the lower "half" of the intake lift. This area is crucial for air flow in that your valve will spend more time in this range than any other. If you make the dome to where the air has a place to go while the piston is finishing the upstroke and starts the downstroke and the dome is not there to interfere because it is moving away and creating a void for the air then you will make good power. Proper shape and size of the dome is what the key is. Don't follow the notion that bigger is always better, here it is shape, area for incoming air -vs- piston location, and proper contouring to allow good laminar flow across the piston, but don't try to make a huge CC to accomodate the piston. Work with an existing CC design that works and manipulate the piston inside the CC area above the bore. You get the combinatin right and you will make power. unfortunately you will probably spend a ton of money getting the sweet spot figured out, that is why I have been using plain old flat tops since 1993. Spent a bunch to have the pistons made went out on a limb and tried it, learned a lot from it though. We still have one blank we may experiment with in a year or so, but for now just using the flatties!